The significance of HTLV-I


Human T-cell lymphotropic virus-I (HTLV-I) is a member of  Retroviridae family, Oncovirinae subfamily. The vast majority of persons infected with HTLV-I (~95%) DO NOT DEVELOP ANY significant DISEASE due to this virus. A small minority, about 1 person in 20, will develop disease; however this usually occurs only after several decades of infection. In very small minority of infected subjects, the virus is associated with two important human diseases: adult T-cell Leukaemia/lymphoma (ATL), and a myelopathy known as HAM/TSP ( HTLV-I associated myelopathy/ tropical spastic parapariesis). However there are some speculations that it can cause infective dermatitis of children and also uveitis.

However, the virus found in the oldest human ethnic groups,  Khorasan prviences in northeast of Iran is an endemic area for this virus. Although, there are speculations for the origin of the virus in this area, still the source of the virus has not been studied, scientifically. Moreover, it has been known that HTLV-I brought in the New World by human migrations 10-20k years ago.

Historically the Silk Roadhas been one of the important parts of the ancient trade routes. It is also a land bridge between the Iranian plateau, central Asia and Indus valley. Therefore, it is possible to investigate if the land routs of this road or the sea routs (more likely) has been facilitated the spreading of HTLV-I in Khorasan.

ستاد HTLV-1

کتاب htlv-1

کتابچه htlv-1


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